Hi Claudia, I’m sorry to hear about your kitty. Just objectively based on your cat’s weight and the dose you mentioned, 2.5mg per day for an 8lb cat would be considered a high dose. Higher doses may be warranted initially in cases where the doctor is concerned about a hypertensive emergency. This is often for blood pressures exceeding 200mmHg or otherwise where we’re concerned we’re seeing acute illness signs directly related to hypertension. I was not clear from your description what the situation was for why it was prescribed at the ER. Just for myself, if I start with a very high dose due to an emergent condition, I try to recheck a blood pressure a couple days later and see if I can reduce the dose. There are certainly some cats that can have persistent or poorly responsive hypertension even at higher doses of amlodipine and sometimes that causes worsening illness. Amlodipine is commonly given to cats with kidney disease (because hypertension and kidney disease can often be related or otherwise, we just see so many older cats with kidney disease) and it really depends on the level of CKD they have as to how much concern to have starting a higher dose. I might be more concerned if she started out with only mild kidney disease and we think it worsened severely in only 10 days. Whereas if she already was in stage 3-4 of CKD, complete failure can occur at any time. It sounds like she tolerated the amlodipine for nearly two weeks before she worsened. That being related to the medication could be possible though hard to be sure of without labwork to demonstrate that. Or, like you said, her kidney disease may have worsened on its own, especially if she was already in a later stage to begin with and that was part of the reason you went to the ER. So, high dose? Yes. Definitively the cause for her worsening? It is a possibility but not possible to be certain and in cats of her age, rapid decline can always occur for any number of reasons. Either way, I am sorry for your loss.

I have used the spray method with success for misbehavior, as well. It worked for me, too. And, my cats were always close to me. They get lots of good attention, so if I yell at them or spray them, they know that they are still very loved and just shouldn’t repeat the behavior.

thank you,
Came up with the same idea, trying to limit access to outside at night early in the evening by blocking flappers off. Of course he started spraying and bad behaviour to show his alpha male. Thank you for replying.

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Hi Theodore,

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